Downregulation of VEGFA accelerates AGEs-mediated nucleus pulposus degeneration through inhibiting protective mitophagy in high glucose environments
Depeng Wu, Weijun Huang, Junbin Zhang, Lei He, Siyu Chen, Sihan Zhu, Yuan Sang, Kaihua Liu, Gang Hou, Biying Chen, Yichun Xu, Bin Liu, Hui Yao
Topics & Concepts
Vascular endothelial growth factor AMitophagyDownregulation and upregulationGene knockdownPI3K/AKT/mTOR pathwayBiologyCell biologyVascular endothelial growth factorCancer researchApoptosisSignal transductionVEGF receptorsBiochemistryAutophagyGeneSpine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationSpinal Hematomas and Complications