Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition
Elias Eger, Michael Schwabe, Lukas Schulig, Nils‐Olaf Hübner, Jürgen A. Bohnert, Uwe T. Bornscheuer, Stefan E. Heiden, Justus U. Müller, Fazal Adnan, Karsten Becker, Carlos L. Correa-Martínez, Sebastian Guenther, Evgeny A. Idelevich, Daniel Baecker, Katharina Schaufler
Abstract
phenotypic approaches, this study revealed the critical role of mutations in a particular porin channel in ceftazidime-avibactam resistance development and a major metabolic regulator for ameliorating fitness and virulence costs. These results highlight underlying mechanisms and contribute to the understanding of factors important for the emergence of successful bacterial pathogens.
Topics & Concepts
Klebsiella pneumoniaeVirulenceBiologyDrug resistanceAntibiotic resistanceMicrobiologyMultilocus sequence typingEffluxCeftazidime/avibactamPathogenCeftazidimeAntibioticsGeneticsGeneBacteriaGenotypeEscherichia coliPseudomonas aeruginosaAntibiotic Resistance in BacteriaEvolution and Genetic DynamicsVibrio bacteria research studies