Low-Frequency Raman Scattering Spectroscopy as an Accessible Approach to Understand Drug Solubilization in Milk-Based Formulations during Digestion
Malinda Salim, Sara J. Fraser‐Miller, Kārlis Bērziņš, Joshua J. Sutton, Gisela Ramirez, Andrew J. Clulow, Adrian Hawley, Stéphane Beilles, Keith C. Gordon, Ben J. Boyd
Abstract
monitoring of drug solubilization in milk and milk-based formulations during digestion can be achieved using low-frequency Raman scattering spectroscopy, and the information obtained from studying this spectral region can provide better insights into drug solubilization compared to the mid-frequency Raman region.
Topics & Concepts
Digestion (alchemy)ChemistryBioavailabilitySmall-angle X-ray scatteringDrugSolubilizationRaman spectroscopyChromatographyAnalytical Chemistry (journal)ScatteringBiochemistryPharmacologyMedicinePhysicsOpticsDrug Solubulity and Delivery SystemsAnalytical Chemistry and ChromatographySpectroscopy and Chemometric Analyses