Radiation-induced abscopal reproductive effect is driven by TNF-α/p38 MAPK/Rac1 axis in Sertoli cells
Songling Hu, Lin Zhu, Yimeng Song, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang, Chunlin Shao
Abstract
Our findings imply for the first time that YWHAZ-mediated Rac1 nuclear translocation plays central roles in RIARE, and TNF-α/p38 MAPK/Rac1 axis can be employed as a therapeutic target against RIARE for young male patients receiving hypofractionated radiotherapy.
Topics & Concepts
Sertoli cellRAC1MAPK/ERK pathwayWestern blotAbscopal effectCancer researchBiologyCell biologyp38 mitogen-activated protein kinasesKinaseSignal transductionEndocrinologyImmunologyImmune systemSpermatogenesisBiochemistryGeneImmunotherapyReproductive Biology and FertilityHeat shock proteins researchSperm and Testicular Function