SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics
R. Karthik, Soumya Maity, Alagar R Muthukumar, Soundarya Kandala, Dhanendra Tomar, Tarek Mohamed Abd El‐Aziz, Cristel Allen, Yuyang Sun, Manigandan Venkatesan, Travis R. Madaris, Kevin Chiem, Rachel Truitt, Neelanjan Vishnu, Gregory J. Aune, Allen A. Anderson, Luis Martínez‐Sobrido, Wenli Yang, James D. Stockand, Brij B. Singh, Subramanya Srikantan, William Reeves, Muniswamy Madesh
Abstract
cycling and cell viability.
Topics & Concepts
MitochondrionEndoplasmic reticulumBiologyCell biologyVoltage-dependent anion channelCoronavirusMitochondrial diseaseMitochondrial membrane transport proteinGene knockdownMitochondrial permeability transition poreMitochondrial DNABiochemistryGeneCoronavirus disease 2019 (COVID-19)Inner mitochondrial membraneDiseaseMedicineInfectious disease (medical specialty)Programmed cell deathBacterial outer membraneApoptosisEscherichia coliPathologyMitochondrial Function and PathologyAutophagy in Disease and TherapyATP Synthase and ATPases Research