Dirhodium(<scp>ii</scp>)-catalysed cycloisomerization of azaenyne: rapid assembly of centrally and axially chiral isoindazole frameworks
Shaotong Qiu, Xiang Gao, Shifa Zhu
Abstract
Rh( ii )-catalyzed asymmetric cycloisomerization of azaenyne through a cap-tether synergistic modulation strategy was described. Diverse centrally and axially chiral isoindazoles were prepared and directed C–H late-stage modifications were developed.
Topics & Concepts
CycloisomerizationChemistryAtropisomerCatalysisAxial chiralityChirality (physics)Nitrogen atomYield (engineering)StereochemistryAxial symmetryCombinatorial chemistryEnantioselective synthesisRing (chemistry)Organic chemistryMaterials sciencePhysicsMetallurgyQuantum mechanicsQuarkNambu–Jona-Lasinio modelChiral symmetry breakingAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis