Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases
Lingxin Zhu, Yi Tang, Xiaoyan Li, Evan T. Keller, Jingwen Yang, Jung‐Sun Cho, Tamar Y. Feinberg, Stephen J. Weiss
Abstract
conditional double-knockout mice exhibited marked increases in bone density and displayed a highly protected status against either parathyroid hormone- or ovariectomy-induced pathologic bone loss. Together, these studies characterize a collagenolytic system operative in mouse and human osteoclasts and identify the MMP9/MMP14 axis as a potential target for therapeutic interventions for bone-wasting disease states.
Topics & Concepts
OsteoclastCathepsin KMatrix metalloproteinaseBone resorptionResorptionMMP9Cell biologyCathepsinChemistryBone remodelingInternal medicineEndocrinologyMedicineBiologyBiochemistryDownregulation and upregulationIn vitroEnzymeGeneBone Metabolism and DiseasesProtease and Inhibitor MechanismsBone and Dental Protein Studies