A multifunctional curcumin–Fe <sub>3</sub> O <sub>4</sub> @ZIF-8 nanoformulation as a <i>T</i> <sub>2</sub> MRI contrast agent and pH-responsive theranostic platform for targeted ROS generation, radiosensitization, and triple-negative breast cancer treatment
Ali Rahmani, Aziz Maleki, Rahim Jafari, Hamed Rezaeejam, Samad Nadri
Abstract
, underscoring its radiosensitization capabilities. Cell cycle analysis revealed G2/M-phase arrest, contributing to impaired cancer cell proliferation. Apoptosis assays confirmed a significant increase in early and late apoptotic populations, while real-time PCR analysis showed significant downregulation of anti-apoptotic BCL-xL and cyclin D1 genes with considerable upregulation of pro-apoptotic BAX, thus reinforcing the mechanism of tumor suppression. This triple-action theranostic system surpasses conventional chemotherapy and standalone MRI contrast agents by combining precision imaging with targeted therapy, offering transformative advancement in TNBC treatment.
Topics & Concepts
Downregulation and upregulationCancer researchApoptosisCyclin D1Viability assayReactive oxygen speciesCytotoxicityChemistryOxidative stressCancerCurcuminBreast cancerRadiation therapyCell cycleCellCancer cellCancer treatmentMedicinePharmacologyDrugCombination therapyDrug deliveryCell cycle checkpointMRI contrast agentCell growthCell cultureMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery