Palladium-Catalyzed Desymmetric Intermolecular C–N Coupling Enabled by a Chiral Monophosphine Ligand Derived from Anthracene Photodimer
Xin Wang, Weigang Liu, Lantao Liu, Xiaodi Yang, Shu Niu, Chen‐Ho Tung, Li‐Zhu Wu, Huan Cong
Abstract
The development of chiral ligands with privileged scaffolds plays an important role in transition-metal-catalyzed asymmetric reactions. Herein we present anthracene-photodimer-derived chiral monophosphine ligand 1, which features dual chirality and a rigid scaffold. This ligand exhibits remarkable efficiency in Pd-catalyzed desymmetric intermolecular C–N coupling under mild conditions with excellent chemo- and enantioselectivity.
Topics & Concepts
ChemistryIntermolecular forceAnthraceneLigand (biochemistry)CatalysisChirality (physics)PalladiumCoupling (piping)Combinatorial chemistryStereochemistryPhotochemistryMoleculeOrganic chemistryReceptorMaterials scienceQuarkChiral symmetry breakingBiochemistryNambu–Jona-Lasinio modelMetallurgyQuantum mechanicsPhysicsCatalytic C–H Functionalization MethodsAxial and Atropisomeric Chirality SynthesisAsymmetric Hydrogenation and Catalysis