Four electrode-based impedimetric biosensors for evaluating cytotoxicity of tamoxifen on cervical cancer cells
Rangadhar Pradhan, Ashish Kalkal, Shlok Jindal, P. Gopinath, S. K. Manhas
Abstract
values obtained from impedimetric data and MTT assay are comparable, signifying that the ECIS technique can be an alternative method to assess the cytotoxicity of different novel drugs. The working principle of the biosensor has been examined by scanning electron microscopy, indicating the detachment of cells from gold surfaces in a dose-dependent manner, signifying the decrease in impedance at higher drug doses.
Topics & Concepts
CytotoxicityTamoxifenBiosensorCervical cancerChemistryCancer researchMedicineCancerInternal medicineBreast cancerBiochemistryIn vitrobioluminescence and chemiluminescence researchAdvanced biosensing and bioanalysis techniquesAnalytical Chemistry and Sensors