Immunological exhaustion: How to make a disparate concept operational?
Hannah Kaminski, Maël Lemoine, Thomas Pradeu
Abstract
In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
Topics & Concepts
EpistemologyBiologyComputational biologyImmunologyComputer sciencePhilosophyCancer, Stress, Anesthesia, and Immune ResponseImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers