Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19)
Elizabeth M. Anderson, Caroline Diorio, Eileen C. Goodwin, Kevin O. McNerney, Madison E. Weirick, Sigrid Gouma, Marcus J. Bolton, Claudia P. Arevalo, Julie Chase, Philip Hicks, Tomaz B. Manzoni, Amy E. Baxter, Kurt P. Andrea, Chakkapong Burudpakdee, Jessica H. Lee, Laura A. Vella, Sarah E. Henrickson, Rebecca M. Harris, E. John Wherry, Paul Bates, Hamid Bassiri, Edward M. Behrens, David T. Teachey, Scott E. Hensley
Abstract
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.