Organocatalytic Cascade β-Functionalization/Aromatization of Pyrrolidines via Double Hydride Transfer
Lan Zhou, Xiao‐De An, Shuo Yang, Xian-Jiang Li, Chang‐Lun Shao, Qing Liu, Jian Xiao
Abstract
An unprecedented cascade β-functionalization/aromatization reaction of N-arylpyrrolidines was established. A series of β-substituted arylpyrroles embedded with trifluoromethyl groups are provided directly from N-arylpyrrolidines. The deuterium-labeling experiments indicate that sequential double hydride transfer processes serve as the key steps in this transformation.
Topics & Concepts
AromatizationChemistrySurface modificationHydrideCascadeTrifluoromethylCombinatorial chemistryDeuteriumTransformation (genetics)Organic chemistryCatalysisHydrogenGenePhysicsPhysical chemistryAlkylBiochemistryChromatographyQuantum mechanicsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis