Photo-Induced Cross-Dehydrogenative Alkylation of Heteroarenes with Alkanes under Aerobic Conditions
Jun Xu, Heng Cai, Jiabin Shen, Chao Shen, Jie Wu, Pengfei Zhang, Xiaogang Liu
Abstract
We report a Minisci-type cross-dehydrogenative alkylation in an aerobic atmosphere using abundant and inexpensive cerium chloride as a photocatalyst and air as an oxidant. This photoreaction exhibits excellent tolerance to functional groups and is suitable for both heteroarene and alkane substrates under mild conditions, generating the corresponding products in moderate-to-good yields. Our method provides an alternative approach for the late-stage functionalization of valuable substrates.
Topics & Concepts
AlkylationCeriumAlkaneChemistryPhotocatalysisPhotochemistryChlorideSurface modificationOrganic chemistryCatalysisPhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsFluorine in Organic Chemistry