Carbocation Footprinting of Soluble and Transmembrane Proteins
Jie Sun, Shuang Li, Weikai Li, Michael L. Gross
Abstract
with the micelle. Carbocation precursors are stable and amenable for tailoring their properties and those of the incipient carbocation, enabling targeting their soluble or membrane-associated or embedded regions and distinguishing between the extra- and trans-membrane domains of membrane proteins.
Topics & Concepts
ChemistryCarbocationFootprintingMicelleDNA footprintingElectrophileTransmembrane proteinStereochemistryCombinatorial chemistryPhotochemistryOrganic chemistryBiochemistryPromoterGene expressionReceptorAqueous solutionCatalysisGeneTranscription factorMass Spectrometry Techniques and ApplicationsReceptor Mechanisms and SignalingAdvanced Proteomics Techniques and Applications