Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII
Tarfah Al‐Warhi, Mostafa M. Elbadawi, Alessandro Bonardi, Alessio Nocentini, Ahmed A. Al‐Karmalawy, Nada Aljaeed, Ohoud J. Alotaibi, Hatem A. Abdel‐Aziz, Claudiu T. Supuran, Wagdy M. Eldehna
Abstract
anticancer properties of the developed CAIs were evaluated.
Topics & Concepts
BenzothiazoleCarbonic anhydraseChemistryStereochemistryMethyleneCarboxylic acidEnzymeLinkerCombinatorial chemistryMedicinal chemistryBiochemistryOperating systemComputer scienceEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities