Ellagic acid-modified gold nanoparticles to combat multi-drug resistant bacterial infections <i>in vitro</i> and <i>in vivo</i>
Yaran Wang, Fan Wu, Yuanfeng Li, Siran Wang, Yijin Ren, Linqi Shi, Henny C. van der Mei, Yong Liu
Abstract
in mice compared to treatment with free EA or gentamicin. Moreover, transcriptome analysis revealed that EA-AuNPs exhibited a multi-targeting mechanism, making resistance development in pathogens more challenging than traditional antibiotics that recognize specific cellular targets. Overall, EA-AuNPs emerged as a promising antimicrobial agent against multi-drug-resistant bacterial infections.
Topics & Concepts
In vivoEllagic acidIn vitroDrugColloidal goldMicrobiologyNanoparticleNanotechnologyChemistryPharmacologyMaterials scienceMedicineBiologyBiochemistryBiotechnologyPolyphenolAntioxidantEssential Oils and Antimicrobial ActivityNanoparticles: synthesis and applicationsBee Products Chemical Analysis