Activation of TGF-β - SMAD2 signaling by IL-6 drives neuroendocrine differentiation of prostate cancer through p38MAPK
Sirisha Natani, K.K. Sruthi, Sakkarai Mohamed Asha, Priyanka Khilar, Pampana Sandhya Venkata Lakshmi, Ramesh Ummanni
Topics & Concepts
LNCaPProstate cancerSMADCancer researchSignal transductionNeuroendocrine differentiationDownregulation and upregulationAndrogen deprivation therapyAndrogen receptorEndocrinologyBiologyCell biologyInternal medicineAndrogenChemistryTransforming growth factorCancer cellApoptosisProstateCytokineCell cultureCellular differentiationSmad2 ProteinCancerReceptorCell signalingTGF-β signaling in diseasesProstate Cancer Treatment and ResearchProstate Cancer Diagnosis and Treatment