Mycobacterium bovis BCG Given at Birth Followed by Inactivated Respiratory Syncytial Virus Vaccine Prevents Vaccine-Enhanced Disease by Promoting Trained Macrophages and Resident Memory T Cells
Yang Wang, Fei Ge, Junhai Wang, Hanglin Li, Boyang Zheng, Wenjian Li, Shunyan Chen, Xiaoqing Zheng, Yuqing Deng, Yueling Wang, Ruihong Zeng
Abstract
RSV is the leading cause of severe lower respiratory tract infection of infants. ERD, characterized by Th2-biased responses, inflammation, and poor immune memory, has been an obstacle to the development of safe and effective killed RSV vaccines.
Topics & Concepts
BiologyVirologyMycobacterium bovisImmune systemVirusRespiratory systemImmunologyVaccinationDiseaseRespiratory tractBCG vaccineImmunological memoryImmunityMycobacterium tuberculosisMicrobiologyTuberculosisMedicineAnatomyPathologyImmune responses and vaccinationsNeonatal Respiratory Health ResearchRespiratory viral infections research