Atom-economical synthesis of 1,2-bis(phosphine oxide)ethanes from calcium carbide with straightforward access to deuterium- and<sup>13</sup>C-labeled bidentate phosphorus ligands and metal complexes
Кристина А. Лоцман, Konstantin S. Rodygin, Irina Skvortsova, Anastasia M. Kutskaya, Mikhail E. Minyaev, Valentine P. Ananikov
Abstract
Straightforward access to bidentate phosphorus ligands and bis(phosphineoxide)ethanes is described based on atom-economic addition reaction. A practical approach was developed to incorporate 2 H and 13 C labels using easily available reagents.
Topics & Concepts
ChemistryDenticityPhosphine oxidePhosphineReagentDeuteriumAtom (system on chip)PhosphorusOxideMetalInorganic chemistryCalcium carbideMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisEmbedded systemPhysicsComputer scienceQuantum mechanicsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisOrganophosphorus compounds synthesis