Litcius/Paper detail

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin, Elisa Barbieri, Deborah A. Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J. Kearney, Jarrod J. Sandow, Zheng Fan, Benjamin J. Blyth, Victoria M. McLeod, Joseph H.A. Vissers, Karolina Pavic, Ben P. Martin, Gareth P. Gregory, Elena Demosthenous, Magnus Zethoven, Isabella Y. Kong, Edwin D. Hawkins, Simon J. Hogg, Madison J. Kelly, Andrea Newbold, Kaylene J. Simpson, Otto Kauko, Kieran F. Harvey, Michael Ohlmeyer, Jukka Westermarck, Nathanael S. Gray, Alessandro Gardini, Ricky W. Johnstone

2021Cell221 citationsDOIOpen Access PDF

Topics & Concepts

RNA polymerase IIBiologyProtein phosphatase 2Cyclin-dependent kinaseTranscription (linguistics)Cell biologyCyclin-dependent kinase 9KinaseCancer researchTranscription factorBRD4PhosphataseMolecular biologyGene expressionCell cyclePhosphorylationProtein kinase ACyclin-dependent kinase 2PromoterGeneBiochemistryBromodomainHistonePhilosophyLinguisticsRNA modifications and cancerCancer-related Molecular PathwaysUbiquitin and proteasome pathways