Metal complexes as a promising source for new antibiotics
Angelo Frei, Johannes Zuegg, Alysha G. Elliott, Murray V. Baker, Stefan Braese, Christopher A. Brown, Feng Chen, Christopher G. Dowson, Gilles Dujardin, Nicole Jung, Anna King, Ahmed M. Mansour, Massimiliano Massi, John Moat, Heba Mohamed, Anna K. Renfrew, Peter J. Rutledge, Peter J. Sadler, Matthew H. Todd, Charlotte E. Willans, Justin J. Wilson, Matthew A. Cooper, Mark A. T. Blaskovich
Abstract
(MRSA). 23 of these complexes have not been reported for their antimicrobial properties before. This work reveals the vast diversity that metal-containing compounds can bring to antimicrobial research. It is important to raise awareness of these types of compounds for the design of truly novel antibiotics with potential for combatting antimicrobial resistance.