SLC5A3 is important for cervical cancer cell growth
Li Li, Fang-rong Shen, Qunxian Cheng, Jing Ping Sun, Hang Li, Hua-ting Sun, Xia Cai, Mengting Chen, Baohua Yang, Lifeng Wang, Ling Xu
Abstract
studies showed that intratumoral injection of SLC5A3 shRNA-expressing virus arrested cervical cancer xenograft growth in mice. SLC5A3 KO also inhibited pCCa-1 cervical cancer xenograft growth. The SLC5A3-depleted xenograft tissues exhibited myo-inositol downregulation, Akt-mTOR inactivation, and oxidative injury. Transduction of sh-TonEBP AAV construct downregulated SLC5A3 expression and inhibited pCCa-1 cervical cancer xenograft growth. Together, overexpressed SLC5A3 promotes growth of cervical cancer cells, representing as a novel therapeutic oncotarget for the devastating disease.
Topics & Concepts
Cancer researchDownregulation and upregulationPI3K/AKT/mTOR pathwayCervical cancerProtein kinase BGene knockdownSmall hairpin RNACancerCell growthCancer cellApoptosisSignal transductionChemistryBiologyMedicineCell biologyInternal medicineBiochemistryGeneCancer-related Molecular PathwaysBladder and Urothelial Cancer TreatmentsWnt/β-catenin signaling in development and cancer