Antibacterial Activity of Dental Composite with Ciprofloxacin Loaded Silver Nanoparticles
Wafa Arif, Nosheen Fatima Rana, Iqra Saleem, Tahreem Tanweer, Muhammad Bilal Khan, Sohad A. Alshareef, Huda Sheikh, Fatima S. Alaryani, Manal O. Al-Kattan, Hanan Ali Alatawi, Farid Menaa, Aroosa Younis Nadeem
Abstract
Resin composites have been widely used in dental restoration. However, polymerization shrinkage and resultant bacterial microleakage are major limitations that may lead to secondary caries. To overcome this, a new type of antibacterial resin composite containing ciprofloxacin-loaded silver nanoparticles (CIP-AgNPs) were synthesized. The chemical reduction approach successfully produced CIP-AgNPs, as demonstrated by FTIR, zeta potential, scanning electron microscopy, and ultraviolet-visible (UV-vis) spectroscopy. CIP-AgNPs were added to resin composites and the antibacterial activity of the dental composite discs were realized against Enterococcus faecalis, Streptococcus mutans, and the Saliva microcosm. The biocompatibility of modified resin composites was assessed and mechanical testing of modified dental composites was also performed. The results indicated that the antibacterial activity and compressive strength of resin composites containing CIP-AgNPs were enhanced compared to the control group. They were also biocompatible when compared to resin composites containing AgNPs. In short, these results established strong ground application for CIP-AgNP-modified dental composite resins.