Palladium-catalyzed remote C–H functionalization of 2-aminopyrimidines
Animesh Das, Akash Jana, Biplab Maji
Abstract
A straightforward strategy was developed for the arylation and olefination at the C5-position of the N-(alkyl)pyrimidin-2-amine core with readily available aryl halides and alkenes, respectively. This approach was highly regioselective, and the transformation was achieved based on two different (Pd(ii)/Pd(iv)) and (Pd(0)/Pd(ii)) catalytic cycles.
Topics & Concepts
PalladiumCatalysisRegioselectivitySurface modificationChemistryArylHalideAlkylAmine gas treatingCombinatorial chemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions