Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells
Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Lévesque, Linda Yingqi Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola Neri, Tolulope O. Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, Esther Mintzer, Stacy A. Maitland, Selami Demirci, Hye Young Ji, Stuart H. Orkin, John F. Tisdale, David A. Williams, Lihua Julie Zhu, Shondra M. Pruett‐Miller, Luca Pinello, J. Keith Joung, Vikram Pattanayak, John Manis, Myriam Armant, Danilo Pellin, Christian Brendel, Scot A. Wolfe, Daniel E. Bauer
Topics & Concepts
BiologyGenome editingEx vivoStem cellHaematopoiesisProgenitor cellCas9Fetal hemoglobinEnhancerGeneticsCRISPRCancer researchCell biologyGeneIn vivoGene expressionFetusPregnancyCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesChromosomal and Genetic Variations