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Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Lévesque, Linda Yingqi Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola Neri, Tolulope O. Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, Esther Mintzer, Stacy A. Maitland, Selami Demirci, Hye Young Ji, Stuart H. Orkin, John F. Tisdale, David A. Williams, Lihua Julie Zhu, Shondra M. Pruett‐Miller, Luca Pinello, J. Keith Joung, Vikram Pattanayak, John Manis, Myriam Armant, Danilo Pellin, Christian Brendel, Scot A. Wolfe, Daniel E. Bauer

2024Cell stem cell24 citationsDOIOpen Access PDF

Topics & Concepts

BiologyGenome editingEx vivoStem cellHaematopoiesisProgenitor cellCas9Fetal hemoglobinEnhancerGeneticsCRISPRCancer researchCell biologyGeneIn vivoGene expressionFetusPregnancyCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesChromosomal and Genetic Variations
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells | Litcius