MiR-126 Regulates Properties of SOX9+ Liver Progenitor Cells during Liver Repair by Targeting Hoxb6
Yi Yan, Rui Wang, Xiongji Hu, Shichao Wang, Liang Zhang, Chenjiao Hou, Lisheng Zhang
Abstract
LPCs fate by targeting Hoxb6 in liver injury repair. Our findings suggest the potential role of miR-126 as a nucleic acid therapy drug target for liver failure.
Topics & Concepts
SOX9BiologyProgenitor cellLiver injuryCancer researchTranscription factorTestis determining factorCell biologyStem cellEndocrinologyGeneticsGeneY chromosomeMicroRNA in disease regulationLiver physiology and pathologyEpigenetics and DNA Methylation