Discovery of highly potent tubulin polymerization inhibitors: Design, synthesis, and structure-activity relationships of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines
Xian‐Sen Huo, Xie‐Er Jian, Jie Ouyang, Lin Chen, Fang Yang, Dong-Xin Lv, Wen‐Wei You, Jinjun Rao, Pei‐Liang Zhao
Topics & Concepts
HeLaChemistryTubulinStereochemistryPyrimidineDocking (animal)Cyclin B1Cyclin-dependent kinase 1Cell cycleMicrotubuleBiochemistryApoptosisIn vitroCell biologyBiologyNursingMedicineSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Biological Evaluation