Regulation of Bacterial Two-Component Systems by Cardiolipin
Won‐Sik Yeo, Sophie Dyzenhaus, Victor J. Torres, Shaun R. Brinsmade, Taeok Bae
Abstract
leads to reduced cytotoxicity to human neutrophils and lower virulence in a mouse model of infection. These findings suggest a model where cardiolipin modulates the kinase activity of SaeS and other sensor kinases after infection to adapt to the hostile environment of the host and expand our knowledge of how phospholipids contribute to membrane protein function.
Topics & Concepts
CardiolipinBiologyComponent (thermodynamics)Bacterial proteinComputational biologyMicrobiologyBacteriaBiochemistryGeneticsMembranePhospholipidPhysicsThermodynamicsLipid Membrane Structure and BehaviorBacterial Genetics and BiotechnologyElectrochemical Analysis and Applications