Phthalazinone-Assisted C–H Amidation Using Dioxazolones Under Rh(III) Catalysis
Daeun Jeoung, Kunyoung Kim, Sang Hoon Han, Prithwish Ghosh, Suk Hun Lee, Saegun Kim, Won Gun An, Hyung Sik Kim, Neeraj Kumar Mishra, In Su Kim
Abstract
The preparation of phthalazinone derivatives is pivotal for their utilization as pharmaceutical agents and other entities. Herein, we report the phthalazinone-assisted carbon–nitrogen bond forming reaction using dioxazolones as robust amidation sources under Rh(III) catalysis. The broad functional group tolerance and complete site-selectivity are observed. Notably, a series of transformations of synthesized compounds into biologically relevant N-heterocycles demonstrates the applicability of the developed methodology.
Topics & Concepts
ChemistryCatalysisMedicinal chemistryStereochemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques