Prognostic role of stromal tumor-infiltrating lymphocytes in locally advanced upper tract urothelial carcinoma: A retrospective multicenter study (TSU-02 study)
Sida Cheng, Wenlong Zhong, Kun Xia, Hong Peng, Rongcheng Lin, Bo Wang, Xinfei Li, Junyu Chen, Zining Liu, Hongxian Zhang, Cheng Liu, Liefu Ye, Lulin Ma, Tianxin Lin, Xuesong Li, Jian Huang, Liqun Zhou
Abstract
= .002). A strongly positive correlation between sTIL density and the expression level of PD-1/PD-L1/CD8 axis was observed. We also found that aristolochic acid (AA) exposure was associated with increased sTIL and elevated PD-L1 expression, indicating that AA-related UTUC might be a distinct subgroup with unique tumor microenvironment characteristics. Our results show that sTIL can be an easily acquired biomarker for prognostic stratification in locally advanced UTUC.
Topics & Concepts
MedicineBiomarkerUrothelial carcinomaInternal medicineOncologyAdjuvantStromal cellRetrospective cohort studyUrologyBladder cancerCancerChemistryBiochemistryBladder and Urothelial Cancer TreatmentsCancer Immunotherapy and BiomarkersInfectious Disease Case Reports and Treatments