STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation
Zhaoping Qiu, Bo Dong, Weijie Guo, Rychahou Piotr, Greg Longmore, Xiuwei H. Yang, Zhiyong Yu, Jiong Deng, B. Mark Evers, Yadi Wu
Abstract
Our study demonstrated that STK39 is a key mediator of SNAI1 stability and is associated with the pro-metastatic cellular process, highlighting the STK39-SNAI1 signaling axis as promising therapeutic targets for treatments of metastatic breast cancer.
Topics & Concepts
SNAI1Cancer researchKinasePhosphorylationEpithelial–mesenchymal transitionMetastasisBreast cancerBiologyIn vivoChemistryCell biologyCancerMedicineInternal medicineBiotechnologyCancer Cells and MetastasisMicrotubule and mitosis dynamicsGenetic factors in colorectal cancer