Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis
Dahai Wang, Mayuri Tanaka-Yano, Eleanor Meader, Melissa A. Kinney, Vivian Morris, Edroaldo Lummertz da Rocha, Nan Liu, Tianxin Liu, Qian Zhu, Stuart H. Orkin, Trista E. North, George Q. Daley, R. Grant Rowe
Abstract
hematopoietic tissues show impairment of B-lymphopoiesis, a precocious adult-like myeloid bias, and that Cbx2/PRC1 regulates developmental timing of expression of key hematopoietic transcription factors. These findings define a mechanism of regulation of HSPC output via chromatin modification as a function of age with potential impact on age-biased pediatric and adult blood disorders.
Topics & Concepts
HaematopoiesisCell biologyBiologyComputational biologyStem cellHematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomicsImmune cells in cancer