Systems mapping of bidirectional endosomal transport through the crowded cell
Marlieke L.M. Jongsma, Nina Bakker, Lenard M. Voortman, Roman I. Koning, Erik Bos, Jimmy J.L.L. Akkermans, Lennert Janssen, Jacques Neefjes
Abstract
and become competent for endosomal capture and minus-end movement in collaboration with membrane-associated Rab7-RILP. We show that endosomes surf over the ER through the crowded cell and move bidirectionally under the control of MAPs for motor activation and through motor replacement and capture by endosomal anchors.
Topics & Concepts
BiologyEndosomeCell biologyComputational biologyIntracellularCellular transport and secretionRetinal Development and DisordersMicrotubule and mitosis dynamics