Treponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and NF-κB signalling pathways
Xin‐Qi Zheng, Xiang-Qi Kong, Yun He, Yongjing Wang, Lin Xie, Li‐Li Liu, Li‐Rong Lin, Tian‐Ci Yang
Topics & Concepts
TLR2PI3K/AKT/mTOR pathwayProtein kinase BCell biologyp38 mitogen-activated protein kinasesCytokineToll-like receptorPhosphorylationSignal transductionBiologyInflammationCancer researchChemistryTLR4ImmunologyImmune systemMAPK/ERK pathwayInnate immune systemSyphilis Diagnosis and TreatmentReproductive tract infections researchImmunodeficiency and Autoimmune Disorders