Direct trifluoromethylthiolation of terminal alkynes mediated by a hypervalent trifluoromethylthio-iodine(<scp>iii</scp>) reagent; boosting effect of fluorinated alcohol
Yu-Xin Cheng, Xiaoguang Yang, Feng‐Huan Du, Chi Zhang
Abstract
We reported a direct simple trifluoromethylthiolation reaction of various terminal alkynes using a new hypervalent trifluoromethylthio-iodine( iii ) reagent TFTI in a fluorinated alcohol, either hexafluoro-2-propanol or perfluoro- tert -butanol.
Topics & Concepts
Hypervalent moleculeReagentIodineChemistryAlcoholOrganic chemistryCombinatorial chemistryFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions