Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens
Zachary Walsh, Parin Shah, Neeharika Kothapalli, Shivem B. Shah, Gergő Nikolényi, D. Zack Brodtman, Giuseppe Leuzzi, Meri Rogava, Michael Mu, Patricia Ho, Sinan Abuzaid, Neil Vasan, Mohammed AlQuraishi, Joshua D. Milner, Alberto Ciccia, Johannes C. Melms, Benjamin Izar
Topics & Concepts
Primary (astronomy)Base (topology)Genome editingBiologyComputational biologyCancer researchGeneticsGeneCRISPRAstronomyMathematicsPhysicsMathematical analysisCAR-T cell therapy researchCRISPR and Genetic EngineeringT-cell and B-cell Immunology