Phase-amplitude coupling in high-gamma frequency range induces LTP-like plasticity in human motor cortex: EEG-TMS evidence
David Baur, Maria Ermolova, Victor H. Souza, Christoph Zrenner, Ulf Ziemann
Abstract
Phase-amplitude coupling (PAC), a ubiquitous phenomenon in human cortex, couples the amplitude of a fast oscillation, usually in the high-gamma frequency range (defined here as 80–200 Hz) to a specific phase of a slower oscillation. PAC is associated with learning and plasticity [1]. One of the most widely used transcranial magnetic stimulation (TMS) protocols, the theta-burst stimulation (TBS), is inspired by the PAC principle, delivering gamma-frequency bursts at theta frequency [2]. However, conventional TBS is not coupled to ongoing brain oscillations.
Topics & Concepts
Transcranial magnetic stimulationTranscranial alternating current stimulationNeuroscienceCoupling (piping)Oscillation (cell signaling)AmplitudeMotor cortexPhysicsPhase (matter)PlasticityHuman brainElectroencephalographyLong-term potentiationNeuroplasticityStimulationNuclear magnetic resonancePsychologyMaterials scienceChemistryOpticsQuantum mechanicsThermodynamicsMetallurgyReceptorBiochemistryNeural dynamics and brain functionTranscranial Magnetic Stimulation StudiesFunctional Brain Connectivity Studies