Mesenchymal stem-cell-derived exosomal miR-145 inhibits atherosclerosis by targeting JAM-A
Wenzhi Yang, Ruihua Yin, Xiaoyan Zhu, Shaonan Yang, Jing Wang, Zhenfeng Zhou, Xudong Pan, Aijun Ma
Abstract
. Our study suggests that MSC-derived miR-145-rich exosomes have great potential for atherosclerosis prevention.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesUmbilical veinmicroRNACancer researchDownregulation and upregulationMedicineHuman umbilical vein endothelial cellExosomeImmunologyIn vivoCell biologyIn vitroBiologyPathologyBiotechnologyBiochemistryGeneExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases