A naphthalimide-based peptide conjugate for concurrent imaging and apoptosis induction in cancer cells by utilizing endogenous hydrogen sulfide
Narendra Singh, Swati Sharma, Ramesh Singh, Swati Rajput, Naibedya Chattopadhyay, Deepshikha Tewari, Khashti Ballabh Joshi, Sandeep Verma
Abstract
, a hydrogen sulfide-sensing naphthalimide-based peptide conjugate (HSNPc), which showed selective inhibition of proliferation of cancer cells due to apoptosis induction. Furthermore, HSNPc suppressed the glycolytic reserve, a critical energy source for the proliferation of cancer cells. HSNPc also decreased the Young's modulus of HeLa cells compared to the control cells, which demonstrated a direct relation between cell apoptosis and cell stiffness. Taken together, we demonstrated the dual function of detection and killing of cancer cells by HSNPc that can be likened to a theranostic role.
Topics & Concepts
Cancer cellEndogenyApoptosisHeLaChemistryCell growthConjugateCancer researchCell biologyGene silencingMetastasisCancerCellBiochemistryBiologyGeneMathematical analysisGeneticsMathematicsSulfur Compounds in BiologyMolecular Sensors and Ion DetectionNanoplatforms for cancer theranostics