Development of a Conformational Histamine H<sub>3</sub> Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists
Hannes Schihada, Xiaoyuan Ma, Ulrike Zabel, Henry F. Vischer, Gunnar Schulte, Rob Leurs, Steffen Pockes, Martin J. Lohse
Abstract
R ligands and can be employed to gain deeper insights into the (in-)activation mechanism of this highly attractive drug target.
Topics & Concepts
Histamine H3 receptorInverse agonistG protein-coupled receptorDrug discoveryAllosteric regulationBiosensorReceptorChemistryHistamineAgonistBiophysicsPharmacologyBiologyBiochemistryReceptor Mechanisms and SignalingMast cells and histamineOlfactory and Sensory Function Studies