Visible light driven deuteration of formyl C–H and hydridic C(sp<sup>3</sup>)–H bonds in feedstock chemicals and pharmaceutical molecules
Yulong Kuang, Hui Cao, Haidi Tang, Junhong Chew, Wei Chen, Xiangcheng Shi, Jie Wu
Abstract
A selective hydrogen deuterium exchange reaction with formyl C–H bonds and a wide range of hydridic C(sp<sup>3</sup>)–H bonds has been achieved by merging tetra-<italic>n</italic>-butylammonium decatungstate photocatalyst and a thiol catalyst under 390 nm light irradiation.
Topics & Concepts
ChemistryMoleculeRaw materialPhotochemistryMedicinal chemistryOrganic chemistryChemical Reactions and IsotopesMass Spectrometry Techniques and ApplicationsMolecular Spectroscopy and Structure