Long non-coding RNA LCAL62 / LINC00261 is associated with lung adenocarcinoma prognosis
Ha X. Dang, Nicole M. White, Emily B. Rozycki, Brooke Felsheim, Mark A. Watson, Ramaswamy Govindan, Jingqin Luo, Christopher A. Maher
Abstract
BACKGROUND: as a prognostic biomarker. PATIENTS AND METHODS: RNA-Seq, microarray, nanoString expression, and clinical data from 1,116 LUAD patients across six independent cohorts and 83 LUAD cell lines were used to discover and evaluate the survival association of metastasis associated lncRNAs. Coexpression and gene set enrichment analyses were used to establish gene regulatory networks and implicate metastasis associated lncRNAs in specific biological processes. RESULTS: = 881) including our own nanoString validation cohort. CONCLUSION: was down-regulated in lung cancer progression to promote invasive phenotypes, and lower expression was significantly associated with poor patient outcome and aggressive lung adenocarcinoma.