Assessments of TP53 and CTNNB1 gene hotspot mutations in circulating tumour DNA of hepatitis B virus-induced hepatocellular carcinoma
Sonu Kumar, Neeti Nadda, Afnan Quadri, Rahul Kumar, Shashi Bala Paul, Pranay Tanwar, Shivanand Gamanagatti, Nihar Ranjan Dash, Anoop Saraya, S. Shalimar, Baibaswata Nayak
Abstract
Screening of ctDNA TP53 and CTNNB1 gene mutations by ddPCR may be helpful for early detection and identifying the risk of HCC progression.
Topics & Concepts
Hepatocellular carcinomaSanger sequencingHepatitis B virusCirrhosisExonLiver cancerMedicineHepatitis BVirologyGeneGene mutationCarcinomaCancer researchVirusMutationBiologyInternal medicineGeneticsCancer Genomics and DiagnosticsPancreatic and Hepatic Oncology ResearchHepatitis B Virus Studies