Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants
Natalie K. Thulin, R. Camille Brewer, Robert Sherwood, Stylianos Bournazos, Karlie Edwards, Nitya S. Ramadoss, Jeffery K. Taubenberger, Matthew J. Memoli, Andrew J. Gentles, Prasanna Jagannathan, Sheng Zhang, Daniel H. Libraty, Taia T. Wang
Abstract
monocytes. These studies identify a post-translational modification of anti-dengue IgGs that correlates with risk for symptomatic infant dengue infections and define a mechanism by which afucosylated antibodies and FcγRIIIa enhance dengue infections.
Topics & Concepts
Dengue feverDengue virusImmunologyMedicineAntibodyAsymptomaticDiseaseAntibody-dependent enhancementVirologyInternal medicineMosquito-borne diseases and controlHIV Research and TreatmentComplement system in diseases