Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition
Qian Zhu, Akanksha Mishra, Joy S. Park, Dongxin Liu, Derek T. Le, Sasha Z. Gonzalez, Morgan Anderson-Crannage, James M. Park, Ho‐Jin Park, Laura Tarbay, Kamron Daneshvar, Matthew Brandenburg, Christina Signoretti, Amy Zinski, Edward-James Gardner, Kelvin Zheng, Chiderah P. Abani, Carla Hu, Cameron Beaudreault, Xiaolei Zhang, Patric K. Stanton, Jun-Hyeong Cho, Libor Velı́šek, Jana Velı́šková, Saqlain Javed, Christopher S. Leonard, Hae-Young Kim, Sangmi Chung
Topics & Concepts
NeuroscienceInduced pluripotent stem cellOptogeneticsGABAergicInterneuronEpilepsyEpilepsy surgeryTranslation (biology)MedicineBiologyEmbryonic stem cellInhibitory postsynaptic potentialBiochemistryGeneMessenger RNAPluripotent Stem Cells ResearchNeuroscience and Neuropharmacology ResearchNeuroscience and Neural Engineering