Regiodivergent Lewis acid catalysis of bicyclo[1.1.0]butanes with 2-naphthols
Lin Fan, Pengyang Wang, Chang He, Xiaoyu Chen, Linlong Dai, Daokai Xiong, Guofu Zhong
Abstract
promotes dearomatization/aromatization to directly access naphthalene-fused BCHs, showcasing remarkable reaction selectivity. Mechanistic studies definitively identify cyclobutyl carbocations as key intermediates. This strategy is anticipated to accelerate the exploration of fused BCH scaffolds in medicinal and synthetic chemistry.
Topics & Concepts
Bicyclic moleculeLewis acids and basesCatalysisChemistryStereochemistryCombinatorial chemistryOrganic chemistryAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsOrganoboron and organosilicon chemistry