Particle-based investigation of excipients stability: the effect of storage conditions on moisture content and swelling
Isra Tayseer, Mark Carroll, Anas Almudahka, James Mann, Alexander Abbott, Fredrik Winge, Adrian Davis, Bart Hens, Ibrahim Khadra, Daniel Markl
Abstract
This study highlights the critical role of moisture and temperature on particle's moisture sorption and moisture-induced swelling advancing our understanding of how excipients contribute to the physical instability of the final dosage form.
Topics & Concepts
SwellingWater contentParticle (ecology)MoistureMaterials scienceComposite materialGeotechnical engineeringEngineeringGeologyOceanographyNatural Fiber Reinforced CompositesMaterial Properties and ProcessingAdvanced Cellulose Research Studies