Copy number analyses of DNA repair genes reveal the role of poly(ADP-ribose) polymerase (PARP) in tree longevity
Yuta Aoyagi Blue, Junko Kusumi, Akiko Satake
Abstract
showed a close association with growth rate. PARPs catalyze poly(ADP-ribosyl)ation and play pivotal roles in DNA repair and antipathogen defense. Our study suggests the conserved role of PARPs in longevity between plants and animals.
Topics & Concepts
LongevityBiologyPARP1DNA repairGeneGeneticsPoly ADP ribose polymeraseDNAGenomeDNA damagePolymeraseDNA Repair MechanismsPARP inhibition in cancer therapy