Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7
Akello J. Agwa, Poanna Tran, Alexander Mueller, Hue N. T. Tran, Jennifer R. Deuis, Mathilde R. Israel, Kirsten L. McMahon, David J. Craik, Irina Vetter, Christina I. Schroeder
Abstract
efficacy similar to that of native HwTx-IV.
Topics & Concepts
Lipid bilayerPotencyChemistryPeptideSodium channelSelectivitySpider toxinGatingBilayerIon channelBiophysicsStereochemistryIn vitroBiochemistryMembraneSodiumReceptorBiologyOrganic chemistryCatalysisGlutamate receptorIon channel regulation and functionNicotinic Acetylcholine Receptors StudyVenomous Animal Envenomation and Studies